Half of women over age 50 in the U.S. will experience a fragility fracture in their lifetime1.
Hip fractures in older women have higher one-year mortality rates than breast cancer2.
Up to half of hip fractures and most wrist fractures occur in women with osteopenia3,4. Osteopenia is much more common than osteoporosis5.
More than 10% of “osteoporosis-related” fractures occur in those with normal or “only” osteopenic BMD6.
What if there was potentially a better way to monitor for the progression of osteopenia and osteoporosis over time to help prevent fragility fractures?
“[Orthopedic] surgeons are uniquely positioned to identify patients at risk of underlying bone health problems during routine practice. …Opportunistic CT [are expected to] lessen the cost of screening, fracture treatment and prevention.” 7
In Development: Convenient, Automated Bone Microstructure Evaluation
InReach fits seamlessly into imaging centers, hospitals, and even the point-of-care setting, improving patient access for screening and monitoring therapy.
OssView is in development to work seamlessly with InReach to provide consistent images, ensuring reliable AI-aided evaluation.
Bone Fragility Assessment
CurveBeam AI is committed to advancing automated imaging tools to evaluate bone microstructure.
In OssView, Region of Interest selection will be automated to ensure consistency.
InReach* scans the wrist.
Deep Learning AI will help extract & identify bones.
Bone microstructure will be segmented.
*HR-mode is required for InReach to be compatible with OssView.
This technology is currently under development and is not yet cleared or approved by the U.S. FDA. Availability is subject to completion of development and applicable regulatory approvals. Regulatory approval and availability may vary by country.
Automated Bone Fragility Analysis with OssView®
OssView Bone Fragility software is under development to analyze InReach images at the distal radius to help evaluate the bone microstructure. OssView is targeted to assess cortical and trabecular density, cortical thickness, and porosity to calculate a Structural Fragility Score (SFS). SFS, if cleared by FDA, could be used as complement to traditional bone mineral density (BMD) tests, allows clinicians an additional tool in assessment of non-osteoporotic women.
OssView has received Breakthrough Device Designation from the US FDA Breakthrough Devices Program. Caution: OssView is not cleared by the FDA for clinical use.
STRUCTURAL SCORE – A POTENTIAL NEW MEASUREMENT FOR ASSESSMENT OF MICROSTRUCTURE
The Structural Fragility Score (SFS), which we are developing to be delivered through OssView, if authorized by FDA is for assessment of bone microstructure. SFS will be calculated from independent measurements of bone microstructure, specifically cortical porosity and trabecular density both extracted from a computed tomography (CT) image at the distal radius.
This technology is currently under development and is not yet cleared or approved by the U.S. FDA. Availability is subject to completion of development and applicable regulatory approvals. Regulatory approval and availability may vary by country.
1 Curtis EM, Moon RJ, Harvey NC, Cooper C. The impact of fragility fracture and approaches to osteoporosis risk assessment worldwide. Bone. 2017 Nov;104:29-38. doi: 10.1016/j.bone.2017.01.024. Epub 2017 Jan 22. PMID: 28119181; PMCID: PMC5420448.
2 Zhang X, Sing CW, Au PC, Tan KC, Wong IC, Cheung CL. Comparing mortality rates, risk, and trends of hip fracture and common cancers in Hong Kong, 2010-2020: A population-based study. Osteoporos Sarcopenia. 2025 Mar;11(1):15-21. doi: 10.1016/j.afos.2024.12.001. Epub 2025 Jan 7. PMID: 40256361; PMCID: PMC12009107.
3. Pasco JA, Seeman E, Henry MJ, Merriman EN, Nicholson GC, Kotowicz MA. The population burden of fractures originates in women with osteopenia, not osteoporosis. Osteoporos Int. 2006;17(9):1404-9. doi: 10.1007/s00198-006-0135-9. Epub 2006 May 13. PMID: 16699736.
4. Crandall CJ, Hovey KM, Andrews CA, Cauley JA, Manson JE, Wactawski-Wende J, Wright NC, Li W, Beavers K, Curtis JR, LeBoff MS. Bone Mineral Density as a Predictor of Subsequent Wrist Fractures: Findings From the Women’s Health Initiative Study. J Clin Endocrinol Metab. 2015 Nov;100(11):4315-24. doi: 10.1210/jc.2015-2568. Epub 2015 Sep 14. PMID: 26367200; PMCID: PMC4702460.
5. Xiao PL, Cui AY, Hsu CJ, Peng R, Jiang N, Xu XH, Ma YG, Liu D, Lu HD. Global, regional prevalence, and risk factors of osteoporosis according to the World Health Organization diagnostic criteria: a systematic review and meta-analysis. Osteoporos Int. 2022 Oct;33(10):2137-2153. doi: 10.1007/s00198-022-06454-3. Epub 2022 Jun 10. PMID: 35687123.
6. Neil Binkley, Robert D Blank, William D Leslie, E Michael Lewiecki, John A Eisman, John P Bilezikian, Osteoporosis in Crisis: It’s Time to Focus on Fracture, Journal of Bone and Mineral Research, Volume 32, Issue 7, 1 July 2017, Pages 1391–1394, https://doi.org/10.1002/jbmr.3182
7. Jessica Ong, Isabel Snee, Isabel Marcano, Scott Tintle, Malek Cheikh, Aviram M. Giladi,
Bone Health, Fragility Fractures, and the Hand Surgeon,
Journal of Hand Surgery Global Online,
Volume 7, Issue 3,
2025,
100709,
ISSN 2589-5141,
https://doi.org/10.1016/j.jhsg.2025.02.002.
(https://www.sciencedirect.com/science/article/pii/S2589514125000283)
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